ChemicalBook > CAS DataBase List > 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Product Name
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
CAS No.
79183-19-0
Chemical Name
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Synonyms
CS-572;MDK83190;APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;Apoptosis Activator 2, >=98%;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP;1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
CBNumber
CB1755989
Molecular Formula
C15H9Cl2NO2
Formula Weight
306.14
MOL File
79183-19-0.mol
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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Property

Boiling point:
470.6±55.0 °C(Predicted)
Density 
1.494
Flash point:
238.4℃
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble in DMSO
pka
-2.69±0.20(Predicted)
form 
Orange to red solid.
Sensitive 
Light Sensitive
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Safety

Safety Statements 
24/25
RIDADR 
3077
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J65320
Product name
Apoptosis Activator 2
Packaging
5mg
Price
$92.1
Updated
2023/06/20
Alfa Aesar
Product number
J65320
Product name
Apoptosis Activator 2
Packaging
25mg
Price
$272
Updated
2021/12/16
Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
5mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
10mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
25mg
Price
$155
Updated
2024/03/01
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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties,Usage,Production

Uses

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

Uses

Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines

Definition

ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).

storage

Room temperature

References

[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Suppliers

China 96 Germany 2 India 2 Italy 1 Switzerland 1 United Kingdom 2 United States 21 Global 125
VDM Biochemicals
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View Lastest Price from 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE manufacturers

Career Henan Chemical Co
Product
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 79183-19-0
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

79183-19-0, 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONERelated Search:

N-METHYLISATIN Indole 1-ETHYL-1H-INDOLE-2,3-DIONE 1-(4-CHLORO-BENZYL)-1H-INDOLE-2,3-DIONE 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-BENZYL-1H-INDOLE-2,3-DIONE 1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-OXIME 1-(2,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 5-CHLORO-1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-(2,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,4-DICHLOROBENZYL)OXIME] 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-OXIME 5-CHLORO-1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,6-DICHLOROBENZYL)OXIME] 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(4-CHLOROBENZYL)OXIME] 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-(N-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZONE) 1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,6-DICHLOROBENZYL)OXIME] 1-(2,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-OXIME

  • APOPTOSIS ACTIVATOR 2
  • APOPTOSIS ACTIVATOR II
  • 1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE
  • 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
  • 1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-
  • Apoptosis Activator 2, >=98%
  • Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer
  • CS-572
  • 1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
  • MDK83190
  • 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP
  • 79183-19-0
  • Inhibitors
  • Caspases/Apoptosis